Novel reciprocal fusion genes involving HNRNPC and RARG in acute promyelocytic leukemia lacking RARA rearrangement
نویسندگان
چکیده
منابع مشابه
A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative geno...
متن کاملAcute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes.
Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciproca...
متن کاملNew variant of acute promyelocytic leukemia with IRF2BP2–RARA fusion
We present an acute promyelocytic leukemia (APL) patient with two subtypes of IRF2BP2-RARA, in which the IRF2BP2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL. However, promyelocytic leukemia-RARA fusion was not detected. A paired-end mRNA sequencing followed by RT-PCR and direct sequencing revealed two types of fusion transcript...
متن کاملOBFC2A/RARA: a novel fusion gene in variant acute promyelocytic leukemia.
Acute promyelocytic leukemia is characterized by the rearrangement of the retinoic acid receptor α (RARA) gene and its fusion with other genes. We report a novel case of variant acute promyelocytic leukemia with the karyotype der (2)t(2;17)(q32;q21). Array comparative genomic hybridization revealed distinct chromosome breakpoints within the RARA and oligonucleotide/oligosaccharide-binding fold ...
متن کاملTranslocation (15;17)(q22;q21) not associated with acute promyelocytic leukemia and negative for PML/RARa rearrangement.
Sir, A 44-year old Chinese man presented with a twoweek history of bone pain and myalgia. Complete blood counts showed: hemoglobin (Hb) 6.3 g/dL, white cell count (WBC) 1.1×109/L (blasts 21%), and platelet count (Plt) 159×109/L. The clotting profile was normal. Bone marrow aspiration revealed a morphologic diagnosis of acute myeloid leukemia-M2 (Figure 1A). Cytochemically, the blast cells were ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Haematologica
سال: 2020
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2019.244715